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(1998) tested four topical treatments on human thigh skin over one month, then took biopsies and examined them under a microscope for procollagen synthesis

APR-246 has been tested in a first-in-man phase I/II clinical trial in patients with hematological malignancies or prostate cancer and shown promising results 13 , and is currently tested in a phase I/II clinical trial in patients with high-grade serous ovarian cancer (www.clinicaltrials.gov)

Further dose increases: After at least 4 weeks on the current dose, the dosage may be increased in 2.5 mg increments

Yes, even one incident can cause irreversible liver scarring